TrkB Recombinant Rabbit Monoclonal Antibody [JE58-22] (ET7111-38)

UNIPROT #

Q16620

PROTEIN NAME

TrkB

SYNONYMS

AI848316 antibody;BDNF tropomyosine receptor kinase B antibody;BDNF/NT 3 growth factors receptor antibody;BDNF/NT-3 growth factors receptor antibody;Brain derived neurotrophic factor receptor antibody;C030027L06Rik antibody;EC 2.7.10.1 antibody;GP145 TrkB antibody;GP145-TrkB antibody;GP145-TrkB/GP95-TrkB antibody;GP95 TrkB antibody;Neurotrophic receptor tyrosine kinase 2 antibody;Neurotrophic tyrosine kinase receptor type 2 antibody;Neurotrophin receptor tyrosine kinase type 2 antibody;NTRK 2 antibody;Ntrk2 antibody;NTRK2_HUMAN antibody;Obesity, hyperphagia, and developmental delay, included antibody;RATTRKB1 antibody;Tkrb antibody;Trk B antibody;Trk-B antibody;TRKB antibody;TrkB tyrosine kinase antibody;TRKB1 antibody;Tropomyosin related kinase B antibody;tyrosine kinase receptor B antibody;Tyrosine receptor kinase B antibody

SUBCELLULAR LOCATION

Cell membrane, Endosome membrane, Early endosome membrane, axon, dendrite, perinuclear region, postsynaptic density.

FUNCTION

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. Isoform GP95-TRKB may also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.