TRIM25 Rabbit Polyclonal Antibody (HA500104)

UNIPROT #

Q14258

PROTEIN NAME

TRIM25

SYNONYMS

E3 ubiquitin/ISG15 ligase TRIM25 antibody;EFP antibody;Estrogen responsive finger protein antibody;Estrogen-responsive finger protein antibody;RING finger protein 147 antibody;RNF 147 antibody;RNF147 antibody;TRI25 antibody;TRI25_HUMAN antibody;TRIM 25 antibody;Trim25 antibody;Tripartite motif containing 25 antibody;Tripartite motif containing protein 25 antibody;Tripartite motif protein TRIM25 antibody;Tripartite motif-containing protein 25 antibody;Tripartite motifcontaining25 antibody;Ubiquitin/ISG15-conjugating enzyme TRIM25 antibody;Z147 antibody;Zinc finger protein 147 (estrogen responsive finger protein) antibody;Zinc finger protein 147 antibody;Zinc finger protein-147 antibody;ZNF 147 antibody;ZNF147 antibody

SUBCELLULAR LOCATION

Cytoplasm, Stress granule.

FUNCTION

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene.