TRIM24 Recombinant Rabbit Monoclonal Antibody [JE64-31] (HA721052)

UNIPROT #

O15164

PROTEIN NAME

TRIM24

SYNONYMS

E3 ubiquitin protein ligase TRIM24 antibody;E3 ubiquitin-protein ligase Trim24 antibody;hTIF1 antibody;PTC6 antibody;RING finger protein 82 antibody;RNF82 antibody;TF1A antibody;TIF1 alpha antibody;TIF1 antibody;TIF1-alpha antibody;TIF1A antibody;TIF1A_HUMAN antibody;TIF1ALPHA antibody;Transcription intermediary factor 1-alpha antibody;Transcriptional intermediary factor 1 alpha antibody;Transcriptional intermediary factor 1 antibody;Trim24 antibody;Tripartite motif containing 24 antibody;Tripartite motif-containing protein 24 antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a protein that, in humans, is encoded by the TRIM24 gene. The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains – a RING, a B-box type 1 and a B-box type 2 – and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. TRIM24 has been shown to interact with Mineralocorticoid receptor, TRIM33, Estrogen receptor alpha and Retinoid X receptor alpha.