PRODUCT CODE: M0809-12

Transthyretin Mouse Monoclonal Antibody [3-E11] (M0809-12)

Applications

  • WB

REACTIVITY

  • Human

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Western blot analysis on human plasma using anti-Transthyretin Mouse mAb (Cat. # M0809-12).
  • Western blot analysis on human plasma using anti-Transthyretin Mouse mAb (Cat. # M0809-12).
Western blot analysis on human plasma using anti-Transthyretin Mouse mAb (Cat. # M0809-12).

Applications

  • WB

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Mouse monoclonal primary

Product Name

Transthyretin Mouse Monoclonal Antibody [3-E11] (M0809-12)

Immunogen

Synthetic peptide (klh-coupled)

Host

Mouse

Positive Control

Human plasma

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

3-E11

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

2 ug/ul

PURIFICATION

Peptide affinity purified

MOLECULAR WEIGHT

16 kDa

Isotype

IgG2b

APPLICATION DILUTION

  • WB

  • 1:5,000

TARGET

UNIPROT #

PROTEIN NAME

Transthyretin

SYNONYMS

Amyloid polyneuropathy antibody; Amyloidosis I antibody; ATTR antibody; Carpal tunnel syndrome 1 antibody; CTS antibody; CTS1 antibody; Dysprealbuminemic euthyroidal hyperthyroxinemia antibody; Dystransthyretinemic hyperthyroxinemia antibody; Epididymis luminal protein 111 antibody; HEL111 antibody; HsT2651 antibody; PALB antibody; Prealbumin amyloidosis type I antibody; Prealbumin antibody; Prealbumin Thyroxine-binding antibody; Senile systemic amyloidosis antibody; TBPA antibody; Thyroxine binding prealbumin antibody; Transthyretin antibody; TTHY_HUMAN antibody; TTR antibody; TTR protein antibody

SEQUENCE SIMILARITIES

Belongs to the transthyretin family.

TISSUE SPECIFICITY

Detected in serum and cerebrospinal fluid (at protein level). Highly expressed in choroid plexus epithelial cells. Detected in retina pigment epithelium and liver.

POST-TRANSLATIONAL MODIFICATION

Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.

SUBCELLULAR LOCATION

secreted

FUNCTION

Transthyretin (TTR) originally called prealbumin is a serum and cerebrospinal fluid carrier of the thyroid hormone thyroxine (T4) and retinol. Prealbumin concentrations are disproportionately high in human ventricular cerebrospinal fluid (CSF). Over 80 different disease-causing mutations in prealbumin have been reported. TTR is known to be associated with the amyloid diseases senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC).