Applications
-
WB
-
IHC-P
REACTIVITY
-
Human
-
Mouse
-
Rat
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
Transmembrane protein 2 Rabbit Polyclonal Antibody (0903-5)
Immunogen
Synthetic peptide within human transmembrane protein 2 aa 98-147 / 1,383.
Host
Rabbit
Positive Control
Mouse heart tissue, rat kidney tissue, human liver tissue, mouse liver tissue, mouse kidney tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Peptide affinity purified.
MOLECULAR WEIGHT
150 kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:1,000-1:2,000
-
IHC-P
-
1:50-1:200
TARGET
UNIPROT #
PROTEIN NAME
Transmembrane protein 2
SYNONYMS
KIAA1412 antibody; TMEM 2 antibody; tmem2 antibody; TMEM2_HUMAN antibody; Transmembrane protein 2 antibody
SEQUENCE SIMILARITIES
Belongs to the CEMIP family.
TISSUE SPECIFICITY
Widely expressed.
SUBCELLULAR LOCATION
Cell membrane. Membrane.
FUNCTION
Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments. Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling. Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate.