Transmembrane protein 2 Rabbit Polyclonal Antibody (0903-5)

Western blot analysis of TMEM2 on mouse heart tissue lysate using anti-TMEM2 antibody at 1/1,000 dilution.

Applications

WB
IHC-P

REACTIVITY

Human
Mouse
Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

Transmembrane protein 2 Rabbit Polyclonal Antibody (0903-5)

Immunogen

This antibody is produced by immunizing rabbits with a synthetic peptide (klh-coupled) corresponding to transmembrane protein 2.

Host

Rabbit

Positive Control

Mouse heart tissue, rat kidney tissue, human liver tissue, mouse liver tissue, mouse kidney tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Peptide affinity purified.

MOLECULAR WEIGHT

150 kDa

Isotype

IgG

APPLICATION DILUTION

WB
1:1,000-1:2,000

IHC-P
1:50-1:200

TARGET

UNIPROT #

Q9UHN6

PROTEIN NAME

Transmembrane protein 2

SYNONYMS

KIAA1412 antibody; TMEM 2 antibody; tmem2 antibody; TMEM2_HUMAN antibody; Transmembrane protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the CEMIP family.

TISSUE SPECIFICITY

Widely expressed.

SUBCELLULAR LOCATION

Cell membrane. Membrane.

FUNCTION

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments. Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling. Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate.