Western blot analysis of TMEM2 on mouse heart tissue lysate using anti-TMEM2 antibody at 1/1,000 dilution.

Applications

WB
IHC-P

REACTIVITY

Human
Mouse
Rat

SPECIFICATIONS

Product Type

Rabbit polyclonal primary

Product Name

Transmembrane protein 2 Rabbit Polyclonal Antibody (0903-5)

Immunogen

Synthetic peptide within human transmembrane protein 2 aa 98-147 / 1,383.

Host

Rabbit

Positive Control

Mouse heart tissue, rat kidney tissue, human liver tissue, mouse liver tissue, mouse kidney tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Peptide affinity purified.

MOLECULAR WEIGHT

150 kDa

Isotype

IgG

APPLICATION DILUTION

WB
1:1,000-1:2,000

IHC-P
1:50-1:200

TARGET

UNIPROT #

Q9UHN6

PROTEIN NAME

Transmembrane protein 2

SYNONYMS

KIAA1412 antibody; TMEM 2 antibody; tmem2 antibody; TMEM2_HUMAN antibody; Transmembrane protein 2 antibody

SEQUENCE SIMILARITIES

Belongs to the CEMIP family.

TISSUE SPECIFICITY

Widely expressed.

SUBCELLULAR LOCATION

Cell membrane. Membrane.

FUNCTION

Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments. Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling. Is very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate.