Transketolase Rabbit Polyclonal Antibody (ER62380)

UNIPROT #

P29401

PROTEIN NAME

Transketolase

SYNONYMS

EC 2.2.1.1 antibody;FLJ34765 antibody;TK antibody;TKT 1 antibody;tkt antibody;TKT_HUMAN antibody;TKT1 antibody;Transketolase (Wernicke Korsakoff syndrome) antibody;Transketolase antibody

SUBCELLULAR LOCATION

Cytosol, endoplasmic reticulum membrane, extracellular exosome, nuclear body, nucleoplasm, peroxisome, vesicle.

FUNCTION

Transketolase (abbreviated as TK) is an enzyme that, in humans, is encoded by the TKT gene. It participates in both the pentose phosphate pathway in all organisms and the Calvin cycle of photosynthesis. Transketolase catalyzes two important reactions, which operate in opposite directions in these two pathways. In the first reaction of the non-oxidative pentose phosphate pathway, the cofactor thiamine diphosphate accepts a 2-carbon fragment from a 5-carbon ketose (D-xylulose-5-P), then transfers this fragment to a 5-carbon aldose (D-ribose-5-P) to form a 7-carbon ketose (sedoheptulose-7-P). The abstraction of two carbons from D-xylulose-5-P yields the 3-carbon aldose glyceraldehyde-3-P. In the Calvin cycle, transketolase catalyzes the reverse reaction, the conversion of sedoheptulose-7-P and glyceraldehyde-3-P to pentoses, the aldose D-ribose-5-P and the ketose D-xylulose-5-P.