Transcription factor AP-2-alpha Recombinant Rabbit Monoclonal Antibody [PSH02-05] (HA721764)

UNIPROT #

P05549

PROTEIN NAME

Transcription factor AP-2-alpha

SYNONYMS

Activating enhancer binding protein 2 alpha antibody;Activating enhancer-binding protein 2-alpha antibody;Activator protein 2 antibody;AP 2 transcription factor antibody;AP 2alpha antibody;AP-2 antibody;AP-2 transcription factor antibody;AP2 antibody;AP2 Transcription Factor antibody;AP2-alpha antibody;AP2A_HUMAN antibody;AP2TF antibody;BOFS antibody;FLJ51761 antibody;TFAP 2 antibody;TFAP 2A antibody;TFAP2 antibody;TFAP2A antibody;Transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha) antibody;Transcription factor AP-2-alpha antibody;Transcription factor AP2 alpha antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.