TRAF3 Recombinant Rabbit Monoclonal Antibody [PSH01-30] (HA721654)

UNIPROT #

Q13114

PROTEIN NAME

TRAF3

SYNONYMS

CAP 1 antibody;CAP-1 antibody;CAP1 antibody;CD40 associated protein 1 antibody;CD40 binding protein antibody;CD40 bp antibody;CD40 receptor associated factor 1 antibody;CD40 receptor-associated factor 1 antibody;CD40-binding protein antibody;CD40BP antibody;CRAF 1 antibody;CRAF1 antibody;IIAE5 antibody;LAP 1 antibody;LAP1 antibody;LMP1 associated protein antibody;LMP1-associated protein 1 antibody;MIPT3 antibody;TNF receptor associated factor 3 antibody;TNF receptor-associated factor 3 antibody;TRAF 3 antibody;Traf3 antibody;TRAF3_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Endosome, Mitochondrion.

FUNCTION

TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene. The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus-encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.