Rabbit polyclonal primary
TRADD Rabbit Polyclonal Antibody (ER1901-79)
Recombinant protein within human tradd aa 109-312 / 312.
Mouse spleen tissue lysates, rat uterus tissue, human kidney tissue, SH-SY5Y, SiHa.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified.
9130005N23Rik antibody;AA930854 antibody;TNFR1 associated DEATH domain protein antibody;TNFR1-associated DEATH domain protein antibody;TNFRSF1A associated via death domain antibody;TNFRSF1A-associated via death domain antibody;tradd antibody;TRADD_HUMAN antibody;Tumor necrosis factor receptor type 1 associated DEATH domain protein antibody;Tumor necrosis factor receptor type 1-associated DEATH domain protein antibody
Found in all examined tissues.
Cytoplasm. Cytoskeleton. Nucleus.
Tumor necrosis factor receptor type 1-associated DEATH domain protein is a protein that in humans is encoded by the TRADD gene. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.