TPPP Recombinant Rabbit Monoclonal Antibody [JE47-35] (ET7109-56)

UNIPROT #

O94811

PROTEIN NAME

TPPP

SYNONYMS

25 kDa brain specific protein antibody;25 kDa brain-specific protein antibody;Brain specific protein p25 alpha antibody;Glycogen synthase kinase 3 (GSK3) inhibitor p24 antibody;OTTHUMP00000161630 antibody;p24 antibody;p25 antibody;p25-alpha antibody;p25alpha antibody;TPPP antibody;TPPP/p25 antibody;TPPP_HUMAN antibody;TPPP1 antibody;Tubulin polymerization promoting protein antibody;Tubulin polymerization-promoting protein antibody

SEQUENCE SIMILARITIES

Belongs to the TPPP family.

TISSUE SPECIFICITY

Widely expressed.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by LIMK1 on serine residues; phosphorylation may alter the tubulin polymerization activity. Phosphorylation by LIMK2, but not LIMK1, regulates astral microtubule organization at early stage of mitosis. Phosphorylation by ROCK1 at Ser-32, Ser-107 and Ser-159 inhibits interaction with HDAC6, resulting in increased acetylation of tubulin, increased cell motility and entry into S-phase. Phosphorylation by CDK1 inhibits the microtubule polymerizing activity.; Degraded by the proteasome; zinc-binding inhibits degradation by the proteasome.

SUBCELLULAR LOCATION

Cytoplasm. Cytoskeleton. Nucleus

FUNCTION

Tubulin polymerization-promoting protein is a protein that in humans is encoded by the TPPP gene. May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown. This protein has been linked to multiple sclerosis myelin lesions and CSF abnormalities in multiple sclerosis patients. This has also been linked to Parkinson's and Alzheimer's Disease.