Topoisomerase II alpha Rabbit Polyclonal Antibody (ER40124)

UNIPROT #

P11388

PROTEIN NAME

Topoisomerase II alpha

SYNONYMS

alpha isozyme antibody;ATP hydrolyzing DNA topoisomerase II alfa antibody;DNA gyrase antibody;DNA topoisomerase (ATP hydrolyzing) antibody;DNA topoisomerase 2 alpha antibody;DNA topoisomerase 2-alpha antibody;DNA topoisomerase II 170 kD antibody;DNA topoisomerase II alpha isozyme antibody;DNA topoisomerase II antibody;DNA Topoisomerase2 antibody;TOP 2A antibody;TOP2 antibody;TOP2A antibody;TOP2A_HUMAN antibody;Topoisomerase DNA II alpha 170kDa antibody;TP2A antibody

SEQUENCE SIMILARITIES

Belongs to the type II topoisomerase family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.

SUBCELLULAR LOCATION

Cytoplasm, nucleus.

FUNCTION

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. It is essential during mitosis and meiosis for proper segregation of daughter chromosomes.