TNF alpha Rabbit Polyclonal Antibody (ER65189)

UNIPROT #

P01375

PROTEIN NAME

TNF-α

SYNONYMS

APC1 antibody;APC1 protein antibody;Cachectin antibody;DIF antibody;Differentiation inducing factor antibody;Macrophage cytotoxic factor antibody;Tnf antibody;TNF superfamily member 2 antibody;TNF superfamily;member 2 antibody;TNF;macrophage derived antibody;TNF;monocyte derived antibody;TNF-a antibody;TNF-alpha antibody;TNFA antibody;TNFA_HUMAN antibody;TNFSF2 antibody;Tumor necrosis factor (TNF superfamily member 2) antibody;Tumor necrosis factor alpha antibody;Tumor necrosis factor antibody;Tumor necrosis factor ligand superfamily member 2 antibody;Tumor Necrosis Factor;Membrane Form antibody;Tumor necrosis factor;soluble form antibody;TNF-α;TNF α

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.