TMS1 / ASC Recombinant Rabbit Monoclonal Antibody [PSH17-34] (HA723917)

UNIPROT #

Q9ULZ3

PROTEIN NAME

TMS1 / ASC

SYNONYMS

Apoptosis associated speck like protein containing a CARD antibody;Apoptosis-associated speck-like protein containing a CARD antibody;ASC antibody;CARD 5 antibody;CARD5 antibody;Caspase recruitment domain containing protein 5 antibody;Caspase recruitment domain protein 5 antibody;Caspase recruitment domain-containing protein 5 antibody;hASC antibody;MGC10332 antibody;PYCARD antibody;PYD and CARD domain containing antibody;PYD and CARD domain containing protein antibody;PYD and CARD domain-containing protein antibody;Target of methylation induced silencing 1 antibody;Target of methylation-induced silencing 1 antibody;TMS 1 antibody;TMS antibody;TMS1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Inflammasome, Endoplasmic reticulum, Mitochondrion, Nucleus.

FUNCTION

PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD), is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, perinuclear space, endoplasmic reticulum and mitochondria and it is a key adaptor protein in activation of the inflammasome.