TMS1 Recombinant Rabbit Monoclonal Antibody [SN07-10] (ET1611-62)

UNIPROT #

Q9ULZ3

PROTEIN NAME

TMS1

SYNONYMS

Apoptosis associated speck like protein containing a CARD antibody;Apoptosis-associated speck-like protein containing a CARD antibody;ASC antibody;ASC_HUMAN antibody;CARD 5 antibody;CARD5 antibody;Caspase recruitment domain containing protein 5 antibody;Caspase recruitment domain protein 5 antibody;Caspase recruitment domain-containing protein 5 antibody;hASC antibody;MGC10332 antibody;PYCARD antibody;PYD and CARD domain containing antibody;PYD and CARD domain containing protein antibody;PYD and CARD domain-containing protein antibody;Target of methylation induced silencing 1 antibody;Target of methylation-induced silencing 1 antibody;TMS 1 antibody;TMS antibody;TMS1 antibody

TISSUE SPECIFICITY

Widely expressed at low levels. Detected in peripheral blood leukocytes, lung, small intestine, spleen, thymus, colon and at lower levels in placenta, liver and kidney. Very low expression in skeletal muscle, heart and brain. Expressed in lung epithelial cells (at protein level). Detected in the leukemia cell lines HL-60 and U-937, but not in Jurkat T-cell lymphoma and Daudi Burkitt's lymphoma. Detected in the melanoma cell line WM35, but not in WM793. Not detected in HeLa cervical carcinoma cells and MOLT-4 lymphocytic leukemia cells.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated.

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Inflammasome, Membrane, Mitochondrion, Nucleus.

FUNCTION

The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. Caspase-associated recruitment domains (CARDs) mediate the interaction between adaptor proteins such as Apaf-1 and the proform of caspases (e.g., CASP9) participating in apoptosis. ASC (apoptosis-associated speck-like protein containing a CARD, also known as TMS1or PYCARD) is a member of the CARD-containing adaptor protein family. ASC is a 195 amino acid protein, containing a N-terminal Pyrin-like domain (PYD) and an 87 residue C-terminal CARD. This motif is characteristic of numerous proteins involved in apoptotic signaling. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation.