PRODUCT CODE: ET1704-11

TLR7 Recombinant Rabbit Monoclonal Antibody [JA93-11] (ET1704-11)

  • Recombinant

Applications

  • WB

REACTIVITY

  • Human

Western blot analysis of TLR7 on Daudi cells lysates using anti-TLR7 antibody at 1/500 dilution.
  • Western blot analysis of TLR7 on Daudi cells lysates using anti-TLR7 antibody at 1/500 dilution.
Western blot analysis of TLR7 on Daudi cells lysates using anti-TLR7 antibody at 1/500 dilution.

Applications

  • WB

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

TLR7 Recombinant Rabbit Monoclonal Antibody [JA93-11] (ET1704-11)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Daudi.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JA93-11

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

140 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

TARGET

UNIPROT #

PROTEIN NAME

TLR7

SYNONYMS

PRO285 antibody; TLR 7 antibody; Tlr7 antibody; TLR7_HUMAN antibody; Toll like receptor 7 antibody; Toll-like receptor 7 antibody; UNQ248 antibody

SEQUENCE SIMILARITIES

Belongs to the Toll-like receptor family.

TISSUE SPECIFICITY

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane.

FUNCTION

The Toll-like Receptors (TLR) are a family of human receptors that share homology with the Drosophila Toll Receptors, which are involved in mediating dorsoventral polarization in developing Drosophila embryos and participate in host immunity. The TLR family members are characterized by a highly conserved Toll homology (TH) domain, which is essential for Toll-induced signal transductions. TLRs are type I transmembrane receptors that contain an extracellular domain consisting of several leucine-rich regions and a single cytoplasmic Toll/IL-1R like domain. Three TLR family members, TLR7, TLR8 and TLR9, belong to a subfamily of TLRs which are differentially expressed. TLR7 is expressed in lung, placenta and spleen. TLR8 is expressed in lung and peripheral blood leukocytes, and TLR9 is predominantly expressed in spleen, lymph nodes, bone marrow and peripheral blood leukocytes. TLR7, TLR8 and TLR9 stimulate the NFκB signaling pathway, suggesting that they play a role in the immune response.