TIRAP Recombinant Rabbit Monoclonal Antibody [JE46-35] (HA722001)

UNIPROT #

P58753

PROTEIN NAME

TIRAP

SYNONYMS

Adapter protein wyatt antibody;FLJ42305 antibody;MAL antibody;MyD88 adapter like protein antibody;TIR domain containing adapter protein antibody;Toll interleukin 1 receptor (TIR) domain containing adaptor protein antibody;Toll interleukin 1 receptor domain containing adapter protein antibody;Toll like receptor adaptor protein antibody;Wyatt antibody

SUBCELLULAR LOCATION

Cytoplasm, Cell membrane, Membrane.

FUNCTION

TIRAP (TIR domain containing adaptor protein) is an adapter molecule associated with toll-like receptors. The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.