TIE2 Recombinant Rabbit Monoclonal Antibody [PSH06-63] (HA722732)

UNIPROT #

Q02763

PROTEIN NAME

TIE2

SYNONYMS

Angiopoietin 1 receptor antibody;Angiopoietin-1 receptor antibody;CD202b antibody;CD202b antigen antibody;Endothelial tyrosine kinase antibody;Endothelium specific receptor tyrosine kinase 2 antibody;hTIE 2 antibody;hTIE2 antibody;Hyk antibody;p140 TEK antibody;Soluble TIE2 variant 1 antibody;Soluble TIE2 variant 2 antibody;Tek antibody;tek tyrosine kinase antibody;TEK tyrosine kinase endothelial antibody;tek tyrosine kinase, endothelial antibody;TIE 2 antibody;TIE2 antibody;TIE2_HUMAN antibody;Tunica interna endothelial cell kinase antibody;Tyrosine kinase with Ig and EGF homology domains 2 antibody;Tyrosine kinase with Ig and EGF homology domains-2 antibody;Tyrosine protein kinase receptor TEK antibody;Tyrosine protein kinase receptor TIE 2 antibody;Tyrosine-protein kinase receptor TEK antibody;Tyrosine-protein kinase receptor TIE-2 antibody;Venous malformations multiple cutaneous and mucosal antibody;VMCM 1 antibody;VMCM antibody;VMCM1 antibody

SUBCELLULAR LOCATION

Cell membrane, Cell junction, focal adhesion, Cytoplasm, cytoskeleton, Secreted.

FUNCTION

Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor. The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. (TEK is closely related to the TIE receptor tyrosine kinase). This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. TEK has also been suggested as a marker for nucleus pulposus progenitor cells, from the intervertebral disc, which upon activation by Angiopoietin-1 starts to multiply and differentiate. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. In cancer patients, TEK (Tie2) is expressed in a subpopulation of monocytes that home in on the tumor and are essential for the formation of new blood vessels there.