TIE-1 Rabbit Polyclonal Antibody (0804-11)
Catalog# 0804-11
Rabbit Polyclonal to TIE-1
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WB
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ICC
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Human
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Mouse
-
Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
TIE-1 Rabbit Polyclonal Antibody (0804-11)
Immunogen
Synthetic peptide within human tie-1 aa 23-72 / 1,138.
Host
Rabbit
Positive Control
K562, HepG2, SW620.
Conjugation
Unconjugated
Clonality
Polyclonal
APPLICATION DILUTION
-
WB
-
1:1,000-1:5,000
-
ICC
-
1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
125kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
TIE-1
SYNONYMS
JKT 14 antibody;JTK14 antibody;TIE antibody;Tie1 antibody;TIE1_HUMAN antibody;Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 antibody;Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains antibody;Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody;Tyrosine protein kinase receptor Tie 1 antibody;Tyrosine-protein kinase receptor Tie-1 antibody
SEQUENCE SIMILARITIES
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
TISSUE SPECIFICITY
Specifically expressed in developing vascular endothelial cells.
POST-TRANSLATIONAL MODIFICATION
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
SUBCELLULAR LOCATION
Cell membrane. Membrane.
FUNCTION
The Tie-1 receptor is an endothelial specific cell surface tyrosine kinase that is indispensable for endothelial functions. Human TIE1 cDNA encodes a 1138 amino acid residue precursor protein with a putative signal peptide, an extracellular domain, and a cytoplasmic domain. Human TIE1/Fc, a disulfide linked homodimeric protein, has a calculated molecular mass of approximately 107 kDa. Tie-1 and Tie-2 are receptor tyrosine kinases (RTKs) that are exclusively expressed in endothelial cells and play important roles in endothelial cell biology.
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