TIE-1 Rabbit Polyclonal Antibody (0804-11)
Catalog# 0804-11
Rabbit Polyclonal to TIE-1
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WB
-
IF-Cell
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Human
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Mouse
-
Rat
Specifications
Product Type
Rabbit polyclonal primary
Product Name
TIE-1 Rabbit Polyclonal Antibody (0804-11)
Immunogen
Synthetic peptide within human tie-1 aa 23-72 / 1,138.
Host
Rabbit
Positive Control
K562, HepG2, SW620.
Conjugation
Unconjugated
Clonality
Polyclonal
APPLICATION DILUTION
-
WB
-
1:1,000-1:5,000
-
IF-Cell
-
1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 25% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 125 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
TIE-1
SYNONYMS
JKT 14 antibody;JTK14 antibody;TIE antibody;Tie1 antibody;TIE1_HUMAN antibody;Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 antibody;Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains antibody;Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 antibody;Tyrosine protein kinase receptor Tie 1 antibody;Tyrosine-protein kinase receptor Tie-1 antibody
SEQUENCE SIMILARITIES
Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily.
TISSUE SPECIFICITY
Specifically expressed in developing vascular endothelial cells.
POST-TRANSLATIONAL MODIFICATION
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
SUBCELLULAR LOCATION
Cell membrane. Membrane.
FUNCTION
Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene. TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells and platelets. TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.
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