Mouse monoclonal primary
Thymidine Phosphorylase Mouse Monoclonal Antibody [A1A10] (EM1901-22)
Recombinant protein within human thymidine phosphorylase aa 19-239 / 482.
A549 cell, human liver carcinoma tissue, human spleen tissue, SiHa cell.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein G purified.
ECGF 1 antibody; ECGF antibody; ECGF1 antibody; Endothelial cell growth factor 1 antibody; Endothelial cell growth factor 1 platelet derived antibody; Endothelial cell growth factor, platelet-derived antibody; Gliostatin antibody; hPD ECGF antibody; MEDPS1 antibody; MNGIE antibody; MTDPS1 antibody; PD ECGF antibody; PD-ECGF antibody; PDECGF antibody; PDEGF antibody; Platelet derived endothelial cell growth factor antibody; Platelet derived endothelial growth factor antibody; Platelet-derived endothelial cell growth factor antibody; TdRPase antibody; Thymidine phosphorylase antibody; TP antibody; Tymp antibody; TYPH_HUMAN antibody
Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.
Platelet-derived endothelial cell growth factor (PD-ECGF), which is alternatively designated thymidine phosphorylase or gliostatin, is an angiogenic inducer that potently stimulates the growth of endothelial cells and induces chemotaxis. Biologically active PD-ECGF is a functional dimer that consists of two single polypeptide chains that are expressed in platelets, placenta, foreskin fibroblasts and various squamous cell carcinomas, and they are slowly secreted from the cells. In addition, PD-ECGF is overexpressed in tumor and lesional psoriatic skin and lesional epidermis, indicating that it may play a role in the pathophysiology of psoriasis. Serine residues of PD-ECGF are frequently associated with nucleotide triphosphates, including ATP. In an ATP dependent manner, PD-ECGF is also able to catalyze the reversible phosphorolysis of thymidine to thymine, as it contains thymidine phosphorylase activities.