Recombinant Rabbit monoclonal primary
Thrombomodulin Recombinant Rabbit Monoclonal Antibody [JB48-23] (ET7107-92)
Human lung cancer tissue, human placenta tissue, A431.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
AHUS 6 antibody; AHUS6 antibody; BDCA 3 antibody; BDCA3 antibody; CD 141 antibody; CD141 antibody; CD141 antigen antibody; Fetomodulin antibody; Thbd antibody; THPH12 antibody; THRM antibody; Thrombomodulin antibody; TM antibody; TRBM_HUMAN antibody
Endothelial cells are unique in synthesizing thrombomodulin.
N-glycosylated.; The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Thrombomodulin (TM), also called CD141, is a type I membrane receptor that is specific to endothelial cells. TM has a cysteine-rich extracellular domain with six EGF-like regions. It forms a complex with Thrombin, which activates Protein C to generate activated Protein C (APC), an anticoagulant enzyme. APC together with Protein S inhibits coagulation by inactivating Factors Va and VIIIa. Deletion of the TM gene results in embryonic lethality in mice.