THOC5 Rabbit Polyclonal Antibody (HA500129)

UNIPROT #

Q13769

PROTEIN NAME

THOC5

SYNONYMS

C22orf19 antibody;Chromosome 22 open reading frame 19 antibody;Fmip antibody;Fms interacting protein antibody;fSAP79 antibody;Functional spliceosome-associated protein 79 antibody;hTREX90 antibody;KIAA0983 antibody;LOC400922 antibody;NF2/meningioma region protein pK1.3 antibody;PK1.3 antibody;Placental protein 39.2 antibody;PP39.2 antibody;THO complex 5 antibody;THO complex subunit 5 antibody;THO complex subunit 5 homolog antibody;thoc5 antibody;THOC5_HUMAN antibody

SUBCELLULAR LOCATION

Nucleus, Cytoplasm.

FUNCTION

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.