Thioredoxin Recombinant Rabbit Monoclonal Antibody [JM10-019] (ET1703-03)

UNIPROT #

P10599

PROTEIN NAME

Thioredoxin

SYNONYMS

ADF antibody;ATL derived factor antibody;ATL-derived factor antibody;DKFZp686B1993 antibody;MGC61975 antibody;SASP antibody;Surface associated sulphydryl protein antibody;Surface-associated sulphydryl protein antibody;testicular tissue protein Li 199 antibody;THIO_HUMAN antibody;Thioredoxin antibody;thioredoxin delta 3 antibody;TRDX antibody;TRX 1 antibody;Trx antibody;TRX1 antibody;TXN antibody;TXN delta 3 antibody;TXN protein antibody;zgc:92903 antibody

SEQUENCE SIMILARITIES

Belongs to the thioredoxin family.

POST-TRANSLATIONAL MODIFICATION

In the fully reduced protein, both Cys-69 and Cys-73 are nitrosylated in response to nitric oxide (NO). When two disulfide bonds are present in the protein, only Cys-73 is nitrosylated. Cys-73 can serve as donor for nitrosylation of target proteins.; In case of infection, ubiquitinated by S.typhimurium protein slrP, leading to its degradation.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Secreted.

FUNCTION

Thioredoxin (Trx) is a redox protein that is found in several species, such as bacteria, plants and mammals, and contains a conserved active site, consisting of Trp-Cys-Gly-Pro-Cys. Trx has several biological functions. It acts as a hydrogen donor for ribonucleotide reductase, which is critical for DNA synthesis, and modulates the DNA-binding activity of several transcription factors, including NFkB, AP-1, p53, TFIIIC and glucocorticoid receptor. Trx also stimulates cell growth, is an inhibitor of apoptosis and plays a role in the protection against oxidative stress. Drugs that inhibit Trx have antitumor activity, suggesting that Trx is involved in a variety of human diseases, including cancer. TrxR is a ubiquitously expressed flavoprotein that catalyzes the NADPH-dependent reduction of Trx as well as several other oxidized cellular components.