PRODUCT CODE: ET7108-45

Tetranectin Recombinant Rabbit Monoclonal Antibody [JG37-16] (ET7108-45)

  • Recombinant

Applications

  • WB

  • ICC

  • IF

  • IHC-P

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

Western blot analysis of Tetranectin on rat skin (1) and human skin (2) tissue lysates using anti-Tetranectin antibody at 1/1,000 dilution.
  • Western blot analysis of Tetranectin on rat skin (1) and human skin (2) tissue lysates using anti-Tetranectin antibody at 1/1,000 dilution.
  • ICC staining Tetranectin in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
  • ICC staining Tetranectin in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
  • Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Tetranectin antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-Tetranectin antibody. Counter stained with hematoxylin.
Western blot analysis of Tetranectin on rat skin (1) and human skin (2) tissue lysates using anti-Tetranectin antibody at 1/1,000 dilution.

Applications

  • WB

  • ICC

  • IF

  • IHC-P

  • IP

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Tetranectin Recombinant Rabbit Monoclonal Antibody [JG37-16] (ET7108-45)

Immunogen

Recombinant protein within human tetranectin aa 100-250.

Host

Rabbit

Positive Control

Rat skin tissue lysate, human skin tissue lysate, HepG2, MCF-7, human liver cancer tissue, human kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JG37-16

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

22 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:1,000-1:5,000

  • ICC

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • IP

  • 1:10-1:50

TARGET

UNIPROT #

PROTEIN NAME

Tetranectin

SYNONYMS

C type lectin domain family 3 member B antibody; C-type lectin domain family 3 member B antibody; Clec3b antibody; Plasminogen kringle 4 binding protein antibody; Plasminogen kringle 4-binding protein antibody; TETN_HUMAN antibody; Tetranectin (plasminogen binding protein) antibody; Tetranectin antibody; TN antibody; TNA antibody

TISSUE SPECIFICITY

Found in plasma.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Tetranectin is a homotrimeric glycoprotein present in plasma and various tissue locations that binds to calcium, heparin, and plasminogen kringle 4. Tetranectin may play a prominent role in tissue remodeling as well as in the regulation of proteolytic processes via its binding and indirect activation of plasminogen. Tetranectin is found in the extracellular matrix (ECM) of certain carcinomas, but is not present in the ECM of normal tissues. Extracellular proteolysis is an important factor in the ability of malignant cells to penetrate normal tissues and metastasize. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and a grim prognosis. Tetranectin may also influence cancer growth by altering activities of plasminogen or the plasminogen fragment, angiostatin which inhibits tumor cell proliferation.