Tet1 Rabbit Polyclonal Antibody (R1510-17)

UNIPROT #

Q8NFU7

PROTEIN NAME

Tet1

SYNONYMS

bA119F7.1 antibody;CXXC 6 antibody;CXXC finger 6 antibody;CXXC type zinc finger protein 6 antibody;CXXC zinc finger 6 antibody;CXXC-type zinc finger protein 6 antibody;CXXC6 antibody;KIAA1676 antibody;LCX antibody;Leukemia associated protein with a CXXC domain antibody;Leukemia-associated protein with a CXXC domain antibody;Methylcytosine dioxygenase TET1 antibody;Ten eleven translocation 1 antibody;Ten eleven translocation 1 gene protein antibody;Ten eleven translocation 1 gene protein homolog antibody;Ten-eleven translocation 1 gene protein antibody;Tet 1 antibody;Tet methylcytosine dioxygenase 1 antibody;Tet oncogene 1 antibody;TET1 antibody;TET1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the TET family.

TISSUE SPECIFICITY

Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain. Up-regulated in glioblastoma cells (at protein level).

POST-TRANSLATIONAL MODIFICATION

Glycosylated. Interaction with OGT leads to GlcNAcylation (By similarity).

SUBCELLULAR LOCATION

Nucleus, Chromosome.

FUNCTION

TET1 (tet oncogene 1), also known as LCX or CXXC6, is a 2,136 amino acid protein that localizes to the nucleus and contains one CXXC-type zinc finger. Expressed in adult ovary, thymus and skeletal muscle and also present in fetal lung, heart and brain, TET1 is thought to play a role in the development of fetal organs and may also be involvement in the pathoegenesis and metastasis of acute myeloid leukemia (AML). The gene encoding TET1 maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman’s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.