TEAD1 Rabbit Polyclonal Antibody (HA500277)

UNIPROT #

P28347

PROTEIN NAME

TEF1

SYNONYMS

AA antibody;Atrophia areata peripapillary chorioretinal degeneration antibody;NTEF 1 antibody;NTEF-1 antibody;NTEF1 antibody;Protein GT IIC antibody;Protein GT-IIC antibody;REF 1 antibody;REF1 antibody;SV40 transcriptional enhancer factor antibody;TCF 13 antibody;TCF-13 antibody;TCF13 antibody;TEA domain family member antibody;TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody;TEA domain family member 1 antibody;TEAD 1 antibody;TEAD 1 protein antibody;TEAD-1 antibody;TEAD1 antibody;TEAD1 protein antibody;TEAD1_HUMAN antibody;TEF 1 antibody;TEF1 antibody;Transcription factor 13 (SV40 transcriptional enhancer factor) antibody;Transcription factor 13 antibody;Transcriptional enhancer factor 1 antibody;Transcriptional enhancer factor TEF-1 antibody;Transcriptional enhancer factor TEF1 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.