Lane 1: SiHa cell lysate
Lane 2: Hela cell lysate
Recombinant Rabbit monoclonal primary
TEF1 Recombinant Rabbit Monoclonal Antibody [JE52-71] (ET7111-04)
Synthetic peptide within n-terminal human tef1.
SiHa cell lysate, Hela cell lysate, A549, MG-63, SiHa, human colon cancer tissue, rat skeletal muscle tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
AA antibody; Atrophia areata peripapillary chorioretinal degeneration antibody; NTEF 1 antibody; NTEF-1 antibody; NTEF1 antibody; Protein GT IIC antibody; Protein GT-IIC antibody; REF 1 antibody; REF1 antibody; SV40 transcriptional enhancer factor antibody; TCF 13 antibody; TCF-13 antibody; TCF13 antibody; TEA domain family member antibody; TEA domain family member 1 (SV40 transcriptional enhancer factor) antibody; TEA domain family member 1 antibody; TEAD 1 antibody; TEAD 1 protein antibody; TEAD-1 antibody; TEAD1 antibody; TEAD1 protein antibody; TEAD1_HUMAN antibody; TEF 1 antibody; TEF1 antibody; Transcription factor 13 (SV40 transcriptional enhancer factor) antibody; Transcription factor 13 antibody; Transcriptional enhancer factor 1 antibody; Transcriptional enhancer factor TEF-1 antibody; Transcriptional enhancer factor TEF1 antibody
Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart.
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.