Lane 1: K562 cell lysate
Lane 2: Hela cell lysate
Recombinant Rabbit monoclonal primary
TDP43 Recombinant Rabbit Monoclonal Antibody [JM51-10] (ET1703-74)
Synthetic peptide within human tdp43 aa 354-390 / 414; (2)aa 253-290 / 414.
K562 cell lysate, Hela cell lysate, 293T, Hela, SH-SY5Y, human spleen tissue, human pancreas tissue, mouse placenta tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
ALS10 antibody; OTTHUMP00000002171 antibody; OTTHUMP00000002172 antibody; OTTHUMP00000002173 antibody; TADBP_HUMAN antibody; TAR DNA binding protein 43 antibody; TAR DNA binding protein antibody; TAR DNA-binding protein 43 antibody; TARDBP antibody; TDP 43 antibody; TDP-43 antibody; TDP43 antibody
Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
Hyperphosphorylated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU. Phosphorylated upon cellular stress.; Ubiquitinated in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.; Cleaved to generate C-terminal fragments in hippocampus, neocortex, and spinal cord from individuals affected with ALS and FTLDU.
DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.