TCP1 delta Mouse Monoclonal Antibody [A8E2] (HA601064)

UNIPROT #

P50991

PROTEIN NAME

TCP1 delta

SYNONYMS

CCT delta antibody;CCT4 antibody;CCTD antibody;chaperonin containing t-complex polypeptide 1, delta subunit antibody;chaperonin containing TCP1, subunit 4 (delta) antibody;SRB antibody;Stimulator of TAR RNA binding antibody;T complex protein 1 subunit delta antibody;TCP-1-delta antibody

SUBCELLULAR LOCATION

Cytoskeleton

FUNCTION

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable). The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin, as well as alpha-transducin (MIM 139330).