TCF7 Recombinant Rabbit Monoclonal Antibody [PSH13-89] (HA723582)

UNIPROT #

P36402

PROTEIN NAME

TCF7

SYNONYMS

FLJ36364 antibody;MGC47735 antibody;OTTHUMP00000159391 antibody;T cell factor 1 antibody;T cell specific transcription factor 1 antibody;T-cell factor 1 antibody;T-cell-specific transcription factor 1 antibody;TCF-1 antibody;TCF-7 antibody;TCF1 antibody;Tcf7 antibody;TCF7 transcription factor 7 antibody;TCF7_HUMAN antibody;Transcription factor 7 (T cell specific HMG box) antibody;Transcription factor 7 antibody;Transcription factor-7, T-cell specific antibody;Transcription factor-7, T-cell specific, 1 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling.