T-bet / Tbx21 Recombinant Rabbit Monoclonal Antibody [JE60-20] (HA721901)

UNIPROT #

Q9UL17

PROTEIN NAME

TBX21

SYNONYMS

T bet antibody;T box 21 antibody;T box expressed in T cells antibody;T box protein 21 antibody;T box transcription factor TBX21 antibody;T cell specific T box transcription factor antibody;T cell specific T box transcription factor T bet antibody;T PET antibody;T-box protein 21 antibody;T-box transcription factor TBX21 antibody;T-cell-specific T-box transcription factor T-bet antibody;TBET antibody;TBLYM antibody;TBX 21 antibody;Tbx21 antibody;TBX21_HUMAN antibody;TPET antibody;Transcription factor TBLYM antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs. Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3. Induces permissive chromatin accessibilty and CpG methylation in IFNG. Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation. Can activate Th1 genes also via recruitment of Mediator complex and P-TEFb (composed of CDK9 and CCNT1/cyclin-T1) in the form of the super elongation complex (SEC) to super-enhancers and associated genes in activated Th1 cells. Inhibits the Th17 cell lineage commitment by blocking RUNX1-mediated transactivation of Th17 cell-specific transcriptinal regulator RORC. Inhibits the Th2 cell lineage commitment by suppressing the production of Th2 cytokines, such as IL-4, IL-5, and IL- 13, via repression of transcriptional regulators GATA3 and NFATC2. Protects Th1 cells from amplifying aberrant type-I IFN response in an IFN-gamma abundant microenvironment by acting as a repressor of type-I IFN transcription factors and type-I IFN-stimulated genes. Acts as a regulator of antiviral B-cell responses; controls chronic viral infection by promoting the antiviral antibody IgG2a isotype switching and via regulation of a broad antiviral gene expression program.