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TAGLN Recombinant Rabbit Monoclonal Antibody (IRS202RB)

Price: Regular price $278.00

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Catalog# IRS202RB

Rabbit Monoclonal to TAGLN

Tested for

  • mIHC

Reacts with

  • Human

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

TAGLN Recombinant Rabbit Monoclonal Antibody (IRS202RB)

Immunogen

Synthetic peptide within human tagln aa 126-175 / 201.

Host

Rabbit

Positive Control

Human skin tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

APPLICATION DILUTION

  • mIHC

  • 1:100

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 23 kDa

Isotype

IgG

TARGET

UNIPROT #

Q01995

PROTEIN NAME

TAGLN

SYNONYMS

22 kDa actin-binding protein antibody;Protein WS3-10 antibody;SM22 antibody;SM22-alpha antibody;Smooth muscle protein 22-alpha antibody;TAGL_HUMAN antibody;TAGLN antibody;Transgelin antibody;WS3-10 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.

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