Lane 1: HT29
Lane 2: Hela
Recombinant Rabbit monoclonal primary
TACC3 Recombinant Rabbit Monoclonal Antibody [SY10-06] (ET1605-18)
Synthetic peptide within human tacc3 aa 40-89 / 838.
HT29, Hela, HepG2, human tonsil tissue, human spleen tissue, mouse testis tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
ERIC 1 antibody; ERIC-1 antibody; ERIC1 antibody; MGC117382 antibody; MGC133242 antibody; OTTHUMP00000113796 antibody; TACC3 antibody; TACC3_HUMAN antibody; Transforming acidic coiled coil containing protein 3 antibody; Transforming acidic coiled-coil-containing protein 3 antibody
Belongs to the TACC family.
TACC1 (transforming acidic coiled coil gene 1) is one of three TACC family members, which are thought to be involved in breast tumorigenesis. TACC1 is located on 8p11 chromosomal region that is amplified in approximately 15% of all breast tumor samples. The short arm of chromosome 8 also contains FGFR1 whose expression is enhanced in most breast cancer tumors. TACC family members, TACC1, TACC2, and TACC3, map very closely to the corresponding FGFR1, FGFR2, FGFR3 genes on chromosomes 8, 10, and 4. Subsequently, since they are phylogenetically related, it is proposed that TACC and FGFR have similar roles in cell growth and differentiation. Also, TACC1 contains a conserved C-terminal region as in the Drosophila homolog, D-TACC. It has been shown that D-TACC is necessary for normal spindle function, and the mammalian TACC proteins appears to interact with centrosomes and microtubules in a similar manner.