TAB3 Rabbit Polyclonal Antibody (HA500421)
Catalog# HA500421
Rabbit Polyclonal to TAB3
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WB
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IHC-P
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Human
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Mouse
Lysates/proteins at 10 µg/Lane.
Predicted band size: 79 kDa
Observed band size: 95 kDa
Exposure time: 30 seconds;
8% SDS-PAGE gel.
Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (HA500421) at 1/500 dilution was used in 5% NFDM/TBST at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:300,000 dilution was used for 1 hour at room temperature.
Specifications
Product Type
Rabbit polyclonal primary
Product Name
TAB3 Rabbit Polyclonal Antibody (HA500421)
Immunogen
Recombinant protein within human tab3 aa 513-712 / 712.
Host
Rabbit
Positive Control
NIH/3T3 cell lysates, human striated muscle tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500
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IHC-P
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1:600
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1.854ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 79 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
TAB3
SYNONYMS
MAP3K7IP 3 antibody;Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 antibody;NAP1 antibody;NF-kappa-B-activating protein 1 antibody;NFkB activating protein 1 antibody;TAB-3 antibody;Tab3 antibody;TAB3_HUMAN antibody;TAK1 binding protein 3 antibody;TAK1-binding protein 3 antibody;TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 antibody;TGF-beta-activated kinase 1-binding protein 3 antibody
SUBCELLULAR LOCATION
Cytosol, extracellular exosome, plasma membrane.
FUNCTION
The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
CITATIONS
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Interleukin-17 promotes osteoclastogenesis and periodontal damage via autophagy in vitro and in vivo
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WB
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Mouse
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Citation
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