SynGAP Rabbit Polyclonal Antibody (ER1902-57)

UNIPROT #

Q96PV0

PROTEIN NAME

SynGAP

SYNONYMS

DKFZp761G1421 antibody;KIAA1938 antibody;MRD5 antibody;Neuronal RasGAP antibody;OTTHUMP00000064825 antibody;p135 SynGAP antibody;Ras GTPase activating protein SynGAP antibody;Ras GTPase-activating protein SynGAP antibody;RASA 1 antibody;RASA 5 antibody;RASA1 antibody;RASA5 antibody;SYGP1_HUMAN antibody;Synaptic Ras GAP 1 antibody;Synaptic Ras GTPase activating protein 1 antibody;Synaptic Ras GTPase activating protein 1 homolog antibody;Synaptic Ras GTPase activating protein 135kDa antibody;Synaptic Ras GTPase activating protein antibody;Synaptic Ras GTPase-activating protein 1 antibody;Synaptic Ras-GAP 1 antibody;SYNGAP 1 antibody;SYNGAP1 antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity (By similarity).

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded by the SYNGAP1 gene. SYNGAP1 is a ras GTPase-activating protein that is critical for the development of cognition and proper synapse function. Mutations in humans can cause intellectual disability or epilepsy. SynGAP1 is a complex protein with several functions that may be regulated temporally via complex isoforms. A well-documented function of SynGAP1 involves NMDA receptor-mediated synaptic plasticity and membrane insertion of AMPA receptors through the suppression of upstream signaling pathways. However, SynGAP1 has also been shown to function cooperatively with Unc51.1 in axon formation. One way SynGAP1 affects these processes is through the MAP kinase signaling pathway by attenuation of Ras signalling. However, alternative splicing and multiple translational start sites have been shown to cause opposing effects, illustrating the importance of multiple functional domains that reside within the c- and n-termini. For example, the expression of an α1 or α2 c-terminal variant of SynGAP1 will either increase or decrease synaptic strength, respectively. Overall, SynGAP1 is essential for development and survival, which is evident as knockout mice die perinatally.