SUZ12 Rabbit Polyclonal Antibody (R1110-2)

UNIPROT #

Q15022

PROTEIN NAME

SUZ12

SYNONYMS

ChET 9 protein antibody;CHET9 antibody;Chromatin precipitated E2F target 9 protein antibody;JJAZ1 antibody;Joined to JAZF1 protein antibody;KIAA0160 antibody;Polycomb protein SUZ12 antibody;Suppressor of zeste 12 homolog antibody;Suppressor of zeste 12 protein homolog antibody;SUZ12 antibody;SUZ12 polycomb repressive complex 2 subunit antibody;SUZ12_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family.

TISSUE SPECIFICITY

Overexpressed in breast and colon cancer.

DEVELOPMENTAL STAGE

Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition.

POST-TRANSLATIONAL MODIFICATION

Sumoylated, probably by PIAS2.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Polycomb protein SUZ12 is a nuclear protein belonging to the VEFS (VRN2-EMF2-FIS2-SUZ12) family. It is overexpressed in breast and colon cancer, expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition. A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer.