Recombinant Rabbit monoclonal primary
SUV39H2 Recombinant Rabbit Monoclonal Antibody [JG36-55] (ET7108-37)
Synthetic peptide within human suv39h2 aa 350 to the c-terminus.
SiHa, A549, mouse testis tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
FLJ23414 antibody; H3 K9 HMTase 2 antibody; H3-K9-HMTase 2 antibody; Histone H3 K9 methyltransferase 2 antibody; Histone H3-K9 methyltransferase 2 antibody; Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody; Histone lysine N methyltransferase SUV39H2 antibody; Histone-lysine N-methyltransferase SUV39H2 antibody; KMT1B antibody; Lysine N methyltransferase 1B antibody; Lysine N-methyltransferase 1B antibody; sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody; Su(var)3 9 Drosophila homolog of 2 antibody; Su(var)3 9 homolog 2 antibody; Su(var)3-9 homolog 2 antibody; Suppressor of variegation 3 9 homolog 2 antibody; Suppressor of variegation 3-9 homolog 2 antibody; Suv39h2 antibody; SUV92_HUMAN antibody
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.