Superoxide Dismutase 3 Recombinant Rabbit Monoclonal Antibody [JE31-84] (HA721408)

UNIPROT #

P08294

PROTEIN NAME

Superoxide Dismutase 3

SYNONYMS

EC SOD antibody;EC-SOD antibody;Extracellular superoxide dismutase [Cu Zn] antibody;Extracellular superoxide dismutase [Cu-Zn] antibody;Extracellular superoxide dismutase antibody;Extracellular superoxide dismutase precursor antibody;MGC20077 antibody;SOD 3 antibody;SOD3 antibody;SODE_HUMAN antibody;Superoxide Dismutase 3 antibody;Superoxide dismutase 3 extracellular antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, Golgi apparatus, trans-Golgi network.

FUNCTION

Extracellular superoxide dismutase [Cu-Zn] is an enzyme that in humans is encoded by the SOD3 gene. This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. Among black garden ants (Lasius niger), the lifespan of queens is an order of magnitude greater than of workers despite no systematic nucleotide sequence difference between them. The SOD3 gene was found to be the most differentially over-expressed gene in the brains of queen vs worker ants. This finding raises the possibility that SOD3 antioxidant activity plays a key role in the striking longevity of social insect queens.