Sterol carrier protein 2 Recombinant Rabbit Monoclonal Antibody [JE62-79] (HA720099)

UNIPROT #

P22307

PROTEIN NAME

Sterol carrier protein 2

SYNONYMS

DKFZp686C12188 antibody;DKFZp686D11188 antibody;NLTP antibody;NLTP_HUMAN antibody;Non-specific lipid-transfer protein antibody;Nonspecific lipid transfer protein antibody;NSL TP antibody;NSL-TP antibody;OTTHUMP00000010488 antibody;OTTHUMP00000231766 antibody;OTTHUMP00000231767 antibody;OTTHUMP00000231768 antibody;OTTHUMP00000231769 antibody;OTTHUMP00000231770 antibody;OTTHUMP00000231772 antibody;OTTHUMP00000231773 antibody;OTTHUMP00000231774 antibody;OTTHUMP00000231776 antibody;OTTHUMP00000234662 antibody;Propanoyl CoA C acyltransferase antibody;Propanoyl-CoA C-acyltransferase antibody;SCP 2 antibody;SCP chi antibody;SCP X antibody;SCP-2 antibody;SCP-chi antibody;SCP-X antibody;SCP2 antibody;SCPchi antibody;SCPX antibody;Sterol carrier protein 2 antibody;Sterol carrier protein X antibody

SUBCELLULAR LOCATION

Cytoplasm, Endoplasmic reticulum, Mitochondrion, Peroxisome.

FUNCTION

This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.