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STAT3 Recombinant Rabbit Monoclonal Antibody [SY24-08] (ET1607-38)

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Catalog# ET1607-38

Rabbit Monoclonal to STAT3

Tested for

  • WB

  • IF-Cell

  • IHC-P

  • FC

Reacts with

  • Human

  • Mouse

  • Rat

  • Zebrafish

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free
Knock-Out or Knock-Down validated
This product has been cited in peer reviewed publications, see list HERE

Safety datasheet

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

STAT3 Recombinant Rabbit Monoclonal Antibody [SY24-08] (ET1607-38)

Immunogen

Synthetic peptide within human stat3 aa 670-710.

Host

Rabbit

Positive Control

CRC, HeLa cell lysate, A431 cell lysate, PANC-1 cell lysate, NIH/3T3 cell lysate, RAW264.7 cell lysate, PC-12 cell lysate, C6 cell lysate, mouse brain tissue, mouse pancreas tissue, rat brain tissue, rat pancreas tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

SY24-08

RRID

AB_3069762

APPLICATION DILUTION

  • WB

  • 1:2,000

  • IF-Cell

  • 1:50-1:200

  • IHC-P

  • 1:50-1:200

  • FC

  • 1μg/mL

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 88 kDa

Isotype

IgG

TARGET

UNIPROT #

P40763

PROTEIN NAME

STAT3

SYNONYMS

1110034C02Rik antibody;Acute Phase Response Factor antibody;Acute-phase response factor antibody;ADMIO antibody;APRF antibody;AW109958 antibody;DNA binding protein APRF antibody;FLJ20882 antibody;HIES antibody;MGC16063 antibody;Signal transducer and activator of transcription 3 (acute phase response factor) antibody;Signal transducer and activator of transcription 3 antibody;STAT 3 antibody;Stat3 antibody;STAT3_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the transcription factor STAT family.

TISSUE SPECIFICITY

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

POST-TRANSLATIONAL MODIFICATION

Tyrosine phosphorylated upon stimulation with EGF. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, LIF, CNTF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha, LEP and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Upon erythropoietin treatment, phosphorylated on Ser-727 by RPS6KA5. Phosphorylation at Tyr-705 by PTK6 or FER leads to an increase of its transcriptional activity. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling.; Acetylated on lysine residues by CREBBP. Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.; Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated.; (Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA.; S-palmitoylated by ZDHHC19 in SH2 putative lipid-binding pockets, leading to homodimerization. Nuclear STAT3 is highly palmitoylated (about 75%) compared with cytoplasmic STAT3 (about 20%).; S-stearoylated, probably by ZDHHC19.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1. Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Shuttles between the nucleus and the cytoplasm.

CITATIONS

  • Cul4 E3 ubiquitin ligase regulates ovarian cancer drug resistance by targeting the antiapoptotic protein BIRC3

  • Liu, Y., Hao, Y., Zhao, H., Zhang, Y., Cheng, D., Zhao, L., Peng, Y., Lu, Y., & Li, Y.

    PlexinA1 activation induced by β2-AR promotes epithelial-mesenchymal transition through JAK-STAT3 signaling in human gastric cancer cells

  • Yun Wah Lam,Shuk Han Cheng

    Estrogen accelerates heart regeneration by promoting the inflammatory response in zebrafish

  • Wang Zhiqian,et al

    TMEM9 promotes lung adenocarcinoma progression via activating the MEK/ERK/STAT3 pathway to induce VEGF expression

  • Resveratrol decreases CD45 CD206 subtype macrophages in LPS-induced murine acute lung injury by SOCS3 signalling pathway.

  • Yongbing Cao,et al

    San Huang Xiao Yan recipe promoted wound healing in diabetic ulcer mice by inhibiting Th17 cell differentiation

  • Ruiqin Hu,et al

    bmp10 maintains cardiac function by regulating iron homeostasis

  • Leptin Gene Protects Against Cold Stress in Antarctic Toothfish

  • Que, H., Hong, W., Lan, T., Zeng, H., Chen, L., Wan, D., Bi, Z., Ren, W., Luo, M., Yang, J., He, C., Zhong, A., & Wei, X.

    Tripterin liposome relieves severe acute respiratory syndrome as a potent COVID-19 treatment

  • Chen, X., Dou, J., Fu, Z., Qiu, Y., Zou, L., Huang, D., & Tan, X.

    Macrophage M1 polarization mediated via the IL-6/STAT3 pathway contributes to apical periodontitis induced by Porphyromonas gingivalis

  • Xiao, X., Zou, S., & Chen, J.

    Cyclic tensile force modifies calvarial osteoblast function via the interplay between ERK1/2 and STAT3

  • Deng, L., Zhang, X., Xiang, X., Xiong, R., Xiao, D., Chen, Z., Liu, K., & Feng, G.

    NANOG Promotes Cell Proliferation, Invasion, and Stemness via IL-6/STAT3 Signaling in Esophageal Squamous Carcinoma

  • Shi Yajing,et al

    Ursolic acid improves necroptosis via STAT3 signaling in intestinal ischemia/reperfusion injury

  • Ming-Ming Zheng,et al

    IMPDH inhibitors upregulate PD-L1 in cancer cells without impairing immune checkpoint inhibitor efficacy

  • Lei Zhu,et al

    Incorporating Network Pharmacology and Experimental Validation to Identify Bioactive Compounds and Potential Mechanisms of Digitalis in Treating Anaplastic Thyroid Cancer

  • Zhaolu Kong

    STAT3 enhances radiation-induced tumor migration,invasion and stem-like properties of bladder cancer

  • Tang Xueqian,et al

    α7nAChR-mediated astrocytic activation: a novel mechanism of Xiongzhi Dilong decoction in ameliorating chronic migraine

  • Huang Jiaxing,et al

    YY1 Lactylation Aggravates Autoimmune Uveitis by Enhancing Microglial Functions via Inflammatory Genes

  • Jinge Dou,et al

    P. Gingivalis induce macrophage polarization by regulating hepcidin expression in chronic apical periodontitis

  • Preparation of Ultra-Small Copper Nanoparticles-Loaded Self-Healing Hydrogels with Antibacterial, Inflammation-Suppressing and Angiogenesis-Enhancing Properties for Promoting Diabetic Wound Healing

  • Liu Zhishuai,et al

    Computer-assisted engineering of stable human leukemia inhibitory factor

  • Bi-Wen Peng

    TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI)

  • Ding, Y., Hu, L., Wang, X., Sun, Q., Hu, T., Liu, J., Shen, D., Zhang, Y., Chen, W., Wei, C., Liu, M., Liu, D., Wang, P., Zhang, C., Zhang, J., Li, Q., & Yang, F.

    The contribution of spinal dorsal horn astrocytes in neuropathic pain at the early stage of EAE

  • Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and β-catenin

  • Li Weijing,et al

    Dexmedetomidine hydrochloride plus sufentanil citrate inhibits glucose metabolism and epithelial‑mesenchymal transition in human esophageal squamous carcinoma KYSE30 cells by modulating the JAK/STAT3/HIF‑1α axis

  • Guozhi Yan,et al

    MIF promotes Th17 cell differentiation in rheumatoid arthritis through ATF6 signal pathway

  • Xiangchen Su,et al

    Microenvironmental pH modulating oxygen self-boosting microalgal prodrug carboxymethyl chitosan/hyaluronic acid/puerarin hydrogel for accelerating wound healing in diabetic rats

  • Wang Yingying,et al

    Linderae Radix extract attenuates ulcerative colitis by inhibiting the JAK/STAT signaling pathway

  • Liu, Z. Y., Lan, T., Tang, F., He, Y. Z., Liu, J. S., Yang, J. Z., Chen, X., Wang, Z. F., & Li, Z. Q.

    ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma

  • Xianlei Han,et al

    Network pharmacology and phytochemical composition combined with validation in vivo and in vitro reveal the mechanism of platycodonis radix ameliorating PM2.5-induced acute lung injury

  • Osteoclast-Derived Exosomal miR-5134-5p Interferes with Alveolar Bone Homeostasis by Targeting the JAK2/STAT3 Axis

  • Jiang Nian,et al

    Gamabufotalin inhibits colitis-associated colorectal cancer by suppressing transcription factor STAT3

  • Peng, T., Wonganan, O., Zhang, Z., Yu, J., Xi, R., Cao, Y., Suksamrarn, A., Zhang, G., & Wang, F.

    A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase. International journal of molecular sciences, 22(7), 3354.

  • Huang, T., Wang, K., Li, Y., Ye, Y., Chen, Y., Wang, J., & Yao, C.

    Construction of a Novel Ferroptosis-Related Gene Signature of Atherosclerosis

  • Ma, P., Zhang, G., Chen, S., Miao, C., Cao, Y., Wang, M., Liu, W., Shen, J., Tang, P. M., Men, Y., Ye, L., & Li, C.

    Promotion effect of TGF-β-Zfp423-ApoD pathway on lip sensory recovery after nerve sacrifice caused by nerve collateral compensation

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