STAT1 Recombinant Mouse Monoclonal Antibody [G3-B11-R] (HA601309)

UNIPROT #

P42224

PROTEIN NAME

STAT1

SYNONYMS

Signal transducer and activator of transcription 1 91kD antibody;CANDF7 antibody;DKFZp686B04100 antibody;IMD31A antibody;IMD31B antibody;IMD31C antibody;ISGF 3 antibody;ISGF-3 antibody;OTTHUMP00000163552 antibody;OTTHUMP00000165046 antibody;OTTHUMP00000165047 antibody;OTTHUMP00000205845 antibody;Signal transducer and activator of transcription 1 91kDa antibody;Signal transducer and activator of transcription 1 antibody;Signal transducer and activator of transcription 1, 91kD antibody;Signal transducer and activator of transcription 1-alpha/beta antibody;STAT 1 antibody;Stat1 antibody;STAT1_HUMAN antibody;STAT91 antibody;Transcription factor ISGF 3 components p91 p84 antibody;Transcription factor ISGF-3 components p91/p84 antibody

SUBCELLULAR LOCATION

Cytoplasm, nucleus

FUNCTION

STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.