SSB Rabbit Polyclonal Antibody (ER2001-50)

UNIPROT #

P05455

PROTEIN NAME

SSB

SYNONYMS

Autoantigen La antibody;La antibody;La autoantigen antibody;La autoantigen homolog antibody;La protein antibody;La ribonucleoprotein antibody;La ribonucleoprotein domain family member 3 antibody;LA_HUMAN antibody;LARP3 antibody;Lupus La antigen antibody;Lupus La protein antibody;Lupus La protein homolog antibody;MGC118101 antibody;MGC93380 antibody;mRNA for autoantigen antibody;OTTMUSP00000014043 antibody;RP23 273G23.1 antibody;Sjoegren syndrome type B antigen antibody;Sjogren syndrome antigen B (autoantigen La) antibody;Sjogren syndrome antigen B antibody;SS B antibody;SS-B antibody;SS-B/La protein antibody;SSB antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.