SREBP1 Rabbit Polyclonal Antibody (HA500210)
Catalog# HA500210
Rabbit Polyclonal to SREBP1
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WB
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IHC-P
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Human
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Mouse
Positive control:
Lane 1: HepG2 cell lysate
Lane 2: Mouse heart tissue lysate
Lane 3: Mouse liver tissue lysate
Lane 4: 293 cell lysate
Lane 5: Jurkat cell lysate
Lane 6: A549 cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
SREBP1 Rabbit Polyclonal Antibody (HA500210)
Immunogen
Synthetic peptide within n-terminal human srebp1 from aa25-aa55.
Host
Rabbit
Positive Control
HepG2 cell lysate, Mouse heart tissue lysate, Mouse liver tissue lysate, 293 cell lysate, Jurkat cell lysate, A549 cell lysate, human lung tissue, human placenta tissue, human adrenal gland tissue, mouse lung tissue, rat liver tissue, rat lung tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:2,000
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IHC-P
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1:100-1:500
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 122 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
SREBP1
SYNONYMS
ADD 1 antibody;bHLHd1 antibody;Class D basic helix-loop-helix protein 1 antibody;D630008H06 antibody;Processed sterol regulatory element-binding protein 1 antibody;SRBP1_HUMAN antibody;SREBF 1 antibody;SREBF1 antibody;SREBP 1 antibody;SREBP 1c antibody;SREBP-1 antibody;SREBP1 antibody;Sterol regulatory element binding protein 1 antibody;Sterol Regulatory Element Binding Transcription Factor 1 / Protein 1 antibody;Sterol regulatory element binding transcription factor 1 antibody;Sterol regulatory element-binding transcription factor 1 antibody
SUBCELLULAR LOCATION
Endoplasmic reticulum membrane, Golgi apparatus membrane, COPII-coated vesicle membrane; Nucleus.
FUNCTION
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively.
CITATIONS
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Yong Yi,et al
DysUFMylation of SREBP1 promotes the progression of hepatocellular carcinoma by reprogramming lipid metabolism
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WB
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Human
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Citation
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Xue Qian,et al
Hexavalent chromium reduces testosterone levels by impairing lipophagy and disrupting lipid metabolism homeostasis: based on a metabolomic analysis
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WB
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Mouse
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Citation
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