SR protein repeat Recombinant Rabbit Monoclonal Antibody [JE61-82] (HA720066)

UNIPROT #

Q13247

PROTEIN NAME

SR protein repeat

SYNONYMS

arginine/serine-rich 6 antibody;B52 antibody;Epididymis secretory protein Li 91 antibody;fc17h09 antibody;HEL S 91 antibody;MGC128807 antibody;MGC5045 antibody;Pre mRNA splicing factor SRP55 antibody;Pre-mRNA-splicing factor SRP55 antibody;Serine/arginine-rich splicing factor 6 antibody;SFRS6 antibody;Splicing factor antibody;Splicing factor arginine/serine rich 55 kDa antibody;Splicing factor arginine/serine rich 6 antibody;SR splicing factor 6 antibody;SRP55 antibody;SRSF6 antibody;SRSF6_HUMAN antibody;wu:faa54g02 antibody;wu:fc17h09 antibody;zgc:103497 antibody

SUBCELLULAR LOCATION

Nucleus, Nucleus speckle.

FUNCTION

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.