Rabbit polyclonal primary
SPATA5L1 Rabbit Polyclonal Antibody (ER1901-68)
Recombinant protein within human spata5l1 aa 360-570.
K562 cell lysates, human liver tissue, Human small intestine tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Predicted band size 80 kDa.
FLJ12286 antibody; MGC5347 antibody; SPA5L_HUMAN antibody; SPATA5L1 antibody; Spermatogenesis-associated protein 5-like protein 1 antibody
Belongs to the AAA ATPase family. AFG2 subfamily.
Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface. Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility. Binds DNA, with a preference for supercoiled DNA and AT-rich DNA. Does not contribute to the internal structure of mitotic chromosomes. May play a role in chromatin organization.