SPATA13 Rabbit Polyclonal Antibody (ER1902-32)

UNIPROT #

Q96N96

PROTEIN NAME

SPATA13

SYNONYMS

APC-stimulated guanine nucleotide exchange factor 2 antibody;ARHGEF29 antibody;Asef2 antibody;FLJ31208 antibody;RP11-307N16.3 antibody;Spata13 antibody;Spermatogenesis-associated protein 13 antibody;SPT13_HUMAN antibody

TISSUE SPECIFICITY

Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.

SUBCELLULAR LOCATION

Cell membrane, Cell projection, Cytoplasm, Membrane.

FUNCTION

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.