SPARC Recombinant Rabbit Monoclonal Antibody [PD00-57] (HA721199)

UNIPROT #

P09486

PROTEIN NAME

SPARC

SYNONYMS

AA517111 antibody;Basement membrane protein 40 antibody;Basement-membrane protein 40 antibody;BM 40 antibody;BM-40 antibody;BM40 antibody;Cysteine rich protein antibody;hm:zeh0062 antibody;MGC128090 antibody;OI17 antibody;ON antibody;Osteonectin antibody;Secreted acidic cystein rich glycoprotein antibody;Secreted protein acidic and cysteine rich antibody;Secreted protein acidic and rich in cysteine antibody;Secreted protein acidic cysteine rich (osteonectin) antibody;Secreted protein acidic cysteine rich antibody;SPARC antibody;SPRC antibody;SPRC_HUMAN antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix, basement membrane.

FUNCTION

This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.