Rabbit polyclonal primary
SOX2 Rabbit Polyclonal Antibody (R1106-1)
F9, MCF-7, NCCIT
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Immunogen affinity purified
ANOP3 antibody; cb236 antibody; Delta EF2a antibody; lcc antibody; MCOPS3 antibody; MGC148683 antibody; MGC2413 antibody; RGD1565646 antibody; Sex determining region Y box 2 antibody; SOX 2 antibody; Sox2 antibody; SOX2_HUMAN antibody; SRY (sex determining region Y) box 2 antibody; SRY box containing gene 2 antibody; SRY related HMG box 2 antibody; SRY related HMG box gene 2 antibody; SRY-box 2 antibody; Transcription factor SOX 2 antibody; Transcription factor SOX-2 antibody; ysb antibody
Sumoylation inhibits binding on DNA and negatively regulates the FGF4 transactivation.
SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential to maintain self-renewal of undifferentiated embryonic stem cells. Sox2, Oct-4 and Nanog co-operate in this network, and siRNA knockdown of either Sox2 or Oct-4 results in loss of pluripotency. POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 are the four Yamanaka factors. When combined, these factors are sufficient to reprogram differentiated cells to an embryonic-like state designated iPS (induced pluripotent stem) cells
Zhu, Xinfeng et al.
All-Trans Retinoic Acid-Induced Deficiency of the Wnt/β-Catenin Pathway Enhances Hepatic Carcinoma Stem Cell Differentiation. | PloS One