SOX10 Mouse Monoclonal Antibody [1-11] (M1311-1)

UNIPROT #

Q04888

PROTEIN NAME

SOX10

SYNONYMS

DOM antibody;DOM antibody;Dominant megacolon mouse human homolog of antibody;MGC15649 antibody;PCWH antibody;SOX 10 antibody;SOX10 antibody;SOX10_HUMAN antibody;SRY (sex determining region Y) box 10 antibody;SRY (sex determining region Y) box 10 antibody;SRY box 10 antibody;SRY box containing gene 10 antibody;SRY related HMG box gene 10 antibody;SRY related HMG box gene 10 antibody;Transcription factor SOX 10 antibody;Transcription factor SOX-10 antibody;WS2E antibody;WS4 antibody;WS4C antibody

TISSUE SPECIFICITY

Expressed in oligodendroglia of the spinal tube (at protein level).

DEVELOPMENTAL STAGE

Expressed in the motor neuron progenitor domain of the spinal tube from 11.5 dpc to postnatal day 6.

SUBCELLULAR LOCATION

Nucleus, cytoplasm

FUNCTION

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease