Sortilin / NT3 Recombinant Rabbit Monoclonal Antibody [PSH06-16] (HA722513)

UNIPROT #

Q99523

PROTEIN NAME

Sortilin / NT3

SYNONYMS

100 kDa NT receptor antibody;Glycoprotein 95 antibody;Gp 95 antibody;Gp95 antibody;LDLCQ6 antibody;Neurotensin receptor 3 antibody;NT 3 antibody;NT3 antibody;NTR 3 antibody;NTR3 antibody;OTTHUMP00000013784 antibody;SORT 1 antibody;SORT_HUMAN antibody;SORT1 (gene name) antibody;Sort1 antibody;Sortilin 1 antibody;Sortilin antibody

SUBCELLULAR LOCATION

Cell membrane. Endoplasmic reticulum. Endosome. Golgi apparatus. Lysosome.

FUNCTION

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.