SMURF1 Rabbit Polyclonal Antibody (HA500057)
Catalog# HA500057
Rabbit Polyclonal to SMURF1
-
WB
-
Human
-
Mouse
-
Rat
Positive control:
Lane 1: NIH/3T3 cell lysate
Lane 2: MCF-7 cell lysate
Lane 3: Rat kidney tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
SMURF1 Rabbit Polyclonal Antibody (HA500057)
Immunogen
Synthetic peptide within human smurf1 aa 30-80.
Host
Rabbit
Positive Control
NIH/3T3 cell lysate, MCF-7 cell lysate, rat kidney tissue lysate.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
-
WB
-
1:500-1:2,000
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size:86 kDa.
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
SMURF1
SYNONYMS
E3 ubiquitin-protein ligase SMURF1 antibody;hSMURF1 antibody;KIAA1625 antibody;Smad specific E3 ubiquitin ligase 1 antibody;SMAD specific E3 ubiquitin protein ligase 1 antibody;Smad ubiquitination regulatory factor 1 antibody;SMAD-specific E3 ubiquitin-protein ligase 1 antibody;SMUF1_HUMAN antibody;SMURF 1 antibody;smurf1 antibody
SUBCELLULAR LOCATION
Cell membrane, Cytoplasm, Membrane.
FUNCTION
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS . Plays a role in dendrite formation by melanocytes .
